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- W2350240192 abstract "Objective: To established a HPLC assay method for the separation and the determination of L - and D - thyroxine enantiomers (L - , and D - T4 ) in thyroid tablets. Method: A normai phase - chiral mobile phase chromatography method has been developed that the method includes extraction of thyroxine from tablet and separation of thyroxine enantiomers on HPLC silica eolumn with chiral eluent containing L - proline, cupric acetate and triethylamine (TEA). Results: The sensitivity of the method was 0. 1 μg ·mL-1. The precision of interday and intarday, linearity, extraction recovery, and stability of T4 enantiomers in thyroxine tablets was determined for the validation of the method. Baseline enantioseparations of compounds containing D - and L - T4 was achieved. We determined the L - , D - T4 concentration of the different lot number of same factor in thyroid tablets. The result showed the different L - , D - T4 concentration in the different lot number thyroid tablets. Conclusiori: The im-proved method is rapid, accurate and reproducible. It is suitable for the quality control of the thyroxine enantiomers in tablets." @default.
- W2350240192 created "2016-06-24" @default.
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- W2350240192 date "2002-01-01" @default.
- W2350240192 modified "2023-09-25" @default.
- W2350240192 title "Determination of D - and L - Thyroxine Enantiomers in Thyroid Tablets with Normal HPLC - Chiral Complexes Exchange Mobile Phase" @default.
- W2350240192 hasPublicationYear "2002" @default.
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