Matches in SemOpenAlex for { <https://semopenalex.org/work/W2350249621> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2350249621 abstract "[Objective]To examine the nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional activity and the protein levels of heme oxygenase 1 (HO-1) and γ-glutamylcysteine synthetase (γ-GCSc) in SH-SY5Y cells induced by lead.[Methods] SH-SY5Y cells cultured in vitro were exposed to 0, 5, 25, and 125μmol/L lead acetate solutions. After 12h and 24h of exposure, cell viability was determined by methly thiazolyl tetrazolium assay, and capacity of Nrf2-antioxidant response element (ARE) binding was measured by electrophoretic mobility shift assay. Western blot was used to detect the protein levels of HO-1 and γ-GCSc.[Results]Compared with the control group, the viability of the lead acetate cultured cells was significantly decreased; the capacity of Nrf2-ARE binding and the protein levels of HO-1 and γ-GCSc were obviously increased (P 0.05).[Conclusion] Lead toxicity in SH-SY5Y cells presents in a dose-dependent manner. Lead can activate the transcriptional activity of Nrf2, and upregulate the expressions of Nrf2-mediated antioxidant enzyme HO-1 and γ-GCSc." @default.
- W2350249621 created "2016-06-24" @default.
- W2350249621 creator A5007878481 @default.
- W2350249621 date "2013-01-01" @default.
- W2350249621 modified "2023-09-23" @default.
- W2350249621 title "Effect of Lead on Transcriptional Activity of Nrf2 and Protein Expression of HO-1 and γ -GCSc in SH-SY5Y Cells" @default.
- W2350249621 hasPublicationYear "2013" @default.
- W2350249621 type Work @default.
- W2350249621 sameAs 2350249621 @default.
- W2350249621 citedByCount "0" @default.
- W2350249621 crossrefType "journal-article" @default.
- W2350249621 hasAuthorship W2350249621A5007878481 @default.
- W2350249621 hasConcept C104317684 @default.
- W2350249621 hasConcept C127561419 @default.
- W2350249621 hasConcept C153911025 @default.
- W2350249621 hasConcept C178790620 @default.
- W2350249621 hasConcept C181199279 @default.
- W2350249621 hasConcept C183978625 @default.
- W2350249621 hasConcept C185592680 @default.
- W2350249621 hasConcept C202751555 @default.
- W2350249621 hasConcept C2776217839 @default.
- W2350249621 hasConcept C2776415932 @default.
- W2350249621 hasConcept C2776715637 @default.
- W2350249621 hasConcept C2778004101 @default.
- W2350249621 hasConcept C2779083432 @default.
- W2350249621 hasConcept C2779219270 @default.
- W2350249621 hasConcept C2779224224 @default.
- W2350249621 hasConcept C29730261 @default.
- W2350249621 hasConcept C53227056 @default.
- W2350249621 hasConcept C54355233 @default.
- W2350249621 hasConcept C55493867 @default.
- W2350249621 hasConcept C81885089 @default.
- W2350249621 hasConcept C86339819 @default.
- W2350249621 hasConcept C86803240 @default.
- W2350249621 hasConceptScore W2350249621C104317684 @default.
- W2350249621 hasConceptScore W2350249621C127561419 @default.
- W2350249621 hasConceptScore W2350249621C153911025 @default.
- W2350249621 hasConceptScore W2350249621C178790620 @default.
- W2350249621 hasConceptScore W2350249621C181199279 @default.
- W2350249621 hasConceptScore W2350249621C183978625 @default.
- W2350249621 hasConceptScore W2350249621C185592680 @default.
- W2350249621 hasConceptScore W2350249621C202751555 @default.
- W2350249621 hasConceptScore W2350249621C2776217839 @default.
- W2350249621 hasConceptScore W2350249621C2776415932 @default.
- W2350249621 hasConceptScore W2350249621C2776715637 @default.
- W2350249621 hasConceptScore W2350249621C2778004101 @default.
- W2350249621 hasConceptScore W2350249621C2779083432 @default.
- W2350249621 hasConceptScore W2350249621C2779219270 @default.
- W2350249621 hasConceptScore W2350249621C2779224224 @default.
- W2350249621 hasConceptScore W2350249621C29730261 @default.
- W2350249621 hasConceptScore W2350249621C53227056 @default.
- W2350249621 hasConceptScore W2350249621C54355233 @default.
- W2350249621 hasConceptScore W2350249621C55493867 @default.
- W2350249621 hasConceptScore W2350249621C81885089 @default.
- W2350249621 hasConceptScore W2350249621C86339819 @default.
- W2350249621 hasConceptScore W2350249621C86803240 @default.
- W2350249621 hasOpenAccess W2350249621 @default.
- W2350249621 hasRelatedWork W1166372783 @default.
- W2350249621 hasRelatedWork W1558003391 @default.
- W2350249621 hasRelatedWork W1623210390 @default.
- W2350249621 hasRelatedWork W2022322175 @default.
- W2350249621 hasRelatedWork W2046336092 @default.
- W2350249621 hasRelatedWork W2049462217 @default.
- W2350249621 hasRelatedWork W2050046023 @default.
- W2350249621 hasRelatedWork W2056221127 @default.
- W2350249621 hasRelatedWork W2062897891 @default.
- W2350249621 hasRelatedWork W2062945711 @default.
- W2350249621 hasRelatedWork W2083159021 @default.
- W2350249621 hasRelatedWork W2087250641 @default.
- W2350249621 hasRelatedWork W2100495567 @default.
- W2350249621 hasRelatedWork W2146736344 @default.
- W2350249621 hasRelatedWork W2383545410 @default.
- W2350249621 hasRelatedWork W2412007760 @default.
- W2350249621 hasRelatedWork W272594083 @default.
- W2350249621 hasRelatedWork W2781338469 @default.
- W2350249621 hasRelatedWork W2994213543 @default.
- W2350249621 hasRelatedWork W68369576 @default.
- W2350249621 isParatext "false" @default.
- W2350249621 isRetracted "false" @default.
- W2350249621 magId "2350249621" @default.
- W2350249621 workType "article" @default.