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- W2350251014 abstract "Objective To evaluate the efficacy and toxicity of concurrent radiotherapy and chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC).Methods Total 184 patients with stage Ⅲ NSCLC were divided randomly into three groups,the radiotherapy(RT) group,the chemotherapy(CT) group,and the radiotherapy+chemotherapy(RT+CT)group.61 cases in the RT group received regular radiotherapy,the total dose was 60 Gy in the local site and the metastatic lymph nodes.61 cases in the CT group recievd paclitaxel plus cisplatin regimen,the chemotherapy was repeated every 28 days and the period of treatment included 6 therapy.63 cases in the RT+CT group recievd concurrent radiotherapy and chemotherapy,the radiotherapy started in the 8th day after chemotherapy,and the treatment regimens were same to the RT group and the CT group.Results The effective rates in the RT+CT,RT and CT group were 76.2%,62.3 amd 56.7% respectively,there was a significant difference between the CT group and the RT+CT group(χ2=5.27,P=0.021).But there was no significant difference between the RT group and the RT+CT group(χ2=2.82,P=0.094).the 1,2 and 3 year survival rates in the RT+CT,RT and CT group were 68.2%,43.3%,19.0%;51.5%,20.5%,7.8%;54.0%,28.0%,10.1% respectively.the median survival time in the three groups were 18,12 and 13 months,and the significance was different among them(χ2=6.26,P=0.039).the concurrent radiotherapy and chemotherapy had more toxicities than the others,but the side effects were well tolerated.Conclusion Paclitaxel combined with cisplatin chemotherapy plus standard radiotherapy can significantly improve the effective rate and survival rate for the patients with advanced non-small cell lung cancer.Although the toxicities increase,the treatment was completed after the expectant administration." @default.
- W2350251014 created "2016-06-24" @default.
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- W2350251014 date "2009-01-01" @default.
- W2350251014 modified "2023-09-23" @default.
- W2350251014 title "Observation on Curative Effects of Concurrent Radiotherapy and Chemotherapy for Advanced Non-small-cell Lung Cancer" @default.
- W2350251014 hasPublicationYear "2009" @default.
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