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- W2350276262 abstract "Objective To investigate the mechanism of the immune response modifier imiquimod.Methods PBLN was isolated and cultured with different concentrations of imiquimod(0.10,1.0,or 10μg/ml)for 0,3,6,12,24 or 48 h.The cell-free supernatants were harvested and expressions of interlukin(IL)-4,IL-5,IL-12 and IFN-γ determined by ELISA.Results Concentrations of IL-12 and IFN-γ were increased significantly by imiquimod of 1.0 and 10μg/ml,while the levels of IL-4 and IL-5 were increased slowly by ovalbumin alone(P0.05).The effect began at 6h,achieved a peak level at 12h,and lasted for 24h.Conclusion Imiquimod shows its effect by marked inhibition of the expression of Th2-type cytokines IL-4,IL-5,and a significant increase of expression of Th1-type cytokines IL-12,IFN-γ.It may be an effective approach in the management of atopic disease." @default.
- W2350276262 created "2016-06-24" @default.
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- W2350276262 date "2005-01-01" @default.
- W2350276262 modified "2023-09-23" @default.
- W2350276262 title "Modulation of Th1 and Th2 cytokine production with imiquimod in the PBLN cell cultures from ovalbumin-sensitized rats" @default.
- W2350276262 hasPublicationYear "2005" @default.
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