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- W2350282301 abstract "目的 观察维拉帕米对大鼠β细胞功能及对甲苯磺丁脲(D860)降糖作用的影响.方法 实验分为对照组、维拉帕米组、D860组以及维拉帕米+D860组,首先在大鼠离体胰岛上观察维拉帕米对胰岛素分泌的作用及其对D860促胰岛素释放的影响.进一步利用静脉葡萄糖耐量试验(IVGTT),在相同实验分组的正常大鼠以急性实验进行验证,并对同组大鼠进行4周的慢性实验,观察慢性给予维拉帕米对大鼠胰岛功能和D860降糖作用的影响,以及胰腺胰岛素含量和胰岛形态学的变化.结果 离体胰岛实验表明,维拉帕米可以抑制胰岛素的释放,维拉帕米组胰岛素为(1.244±0.082)ng·ml-1·胰岛-1,对照组为(2.623±0.226)ng·ml-1·胰岛-1(P＜0.05);维拉帕米+D860组(3.264±0.284)ng·ml-1·胰岛-1(与对照组相比,P＞0.05);急性动物实验也有类似的结果,维拉帕米减弱D860的降糖作用.但用药4周未产生相同的作用,并且不改变胰腺胰岛素含量和胰岛形态学变化.结论 维拉帕米慢性应用对大鼠胰岛功能及D860的降糖作用无明显影响." @default.
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