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- W2350288254 abstract "Exposure to the external aqueous environment enhances the susceptibility to infectious diseases in fish gills. To understand the mechanism of local innate immunity against infectious grass carp reovirus (GCRV) in the gills, we identified the partial cDNA sequence of Mx, an antiviral effector molecule, in rare minnow Gobiocypris rarus. Real-time quantitative RT-PCR (qRT-PCR) was employed to quantitate mRNA levels of a pattern recognition receptor, Toll-like receptor 3(TLR3), and type I interferons indicator molecule Mx. The artificial infection experiments revealed that TLR3 and Mx mRNA expressions were simultaneously significant up-regulation at 12h postinjection (p＜0.05), the transcription level of TLR3 recovered at 48h postinjection (p＞0.05), and the Mx mRNA expression kept at high transcription level till moribund (p＜0.05). These results highlighted the importance of the gills as a tissue capable of mounting a local immune response, and the interferon pathway was activated to GCRV infection." @default.
- W2350288254 created "2016-06-24" @default.
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- W2350288254 date "2008-09-01" @default.
- W2350288254 modified "2023-09-27" @default.
- W2350288254 title "UP-REGULATING EXPRESSIONS OF TOLL-LIKE RECEPTOR 3 AND MX GENES IN GILLS BY GRASS CARP REOVIRUS IN RARE MINNOW, GOBIOCYPRIS RARUS" @default.
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