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- W2350293455 abstract "AIM: To analyze the changes of nitric oxide (NO) and nitric oxide synthase (NOS) after ischemia reperfusion injury of the normal liver and neoplasm and to explore the influence of the ischemia reperfusion on the hepatic neoplasm. METHODS: Hepatic neoplasm animal model was established by ultrasonography guided implantation of VX 2 tumor constitution mass into the left middle lobe of liver of the rabbits. Ischemia was caused by using a non traumatic vascular clamp to block the branches in the left middle lobe of the hepatic artery for 60 min, and then the clamp was removed and the reperfusion injury of the hepatic neoplasm occurred. The animal models were randomly divided into the control group (before ischemia and reperfusion), and 0 min, 1 h, 1 d, 3 d and 7 d groups after ischemia reperfusion, and then their normal and hepatic neoplasm tissues were harvested to detect NO and NOS respectively. RESULTS: NO concentration of hepatic tissue of all groups except 1 h group was lower than that in control group and changed a little. The NO concentration of neoplasm tissue decreased after ischemia reperfusion and reached the lowest level at 1 h and then restored gradually, but retained the lower level than that in the control group at 7 d( P 0.01). The NOS concentration of hepatic tissue including eNOS, nNOS and iNOS decreased a little, but iNOS concentration decreased apparently from 0 min to 1 h ( P 0.01), however, it did not restore to the normal level of control group at 7 d yet. The NOS concentration of neoplasm tissue first decreased below the normal level at 0 min and then rose over it from 1 d to 7 d( P 0.01), but iNOS concentration rose continuously and beyond the normal level after ischemia reperfusion injury from 0 min to 7 d ( P 0.01). CONCLUSION: Neoplasm tissue is injured much more than hepatic tissue after ischemia reperfusion; NO play an injurious roles during the process of ischemia reperfusion of neoplasm tissue; and iNOS is the key modulator in producing NO of the neoplasm." @default.
- W2350293455 created "2016-06-24" @default.
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- W2350293455 date "2003-01-01" @default.
- W2350293455 modified "2023-09-23" @default.
- W2350293455 title "Changes of NO and NOS after ischemia reperfusion injury of hepatic neoplasm and its implications" @default.
- W2350293455 hasPublicationYear "2003" @default.
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