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- W2350301713 abstract "Objective:To observe oxidative stress induced by intravenous iron and its prevention by lycopene in maintenance hemodialysis(MHD) patients.Methods:30 MHD patients were randomly divided into two groups:control group(n=15) and treatment group(n=15).In control group,the patients were treated with iron sucrose 100mg intravenously,during 10 consecutive hemodialysis sessions,twice a week for five weeks.In treatment group,in addition to intravenous iron,the patients were given lycopene,2# orally,twice a day for eight weeks.Their hemoglobin(Hb),hematocrit(Hct),serum iron(SI),serum ferritin(SF),transferring saturation(TAST),superoxide dismutase(SOD),glutathione peroxidase(GSH-px) and malondialdehyde(MDA) levels were measured at pre-and post-treatment.Results:Compared with those in the pre-treatment,the levels of serum SOD and GSH-px in both groups decreased markedly(P0.01).but the descent range of serum SOD and GSH-px in treatment group was less than those in control group(P0.01).Compared with those at the pre-treatment,the levels of serum MDA in both groups were elevated significantly(P0.01).but the increament rate of MDA in treatment group was less than that in control group(P0.01).At post-treatment,the levels of serum MDA were positively correlated to the levels of SF in both groups(P0.01).Compared with those in the pre-treatment,the levels of Hb,Hct,SI,SF,and TSAT increased significantly in both groups(P0.01) at post-treatment.Moreover,the increament rates of them were not significantly different between both of groups.Conclusion:Intravenous iron therapy could induce aggravation of oxidative stress in MHD patients,which could be alleviated by lycopene." @default.
- W2350301713 created "2016-06-24" @default.
- W2350301713 creator A5032356382 @default.
- W2350301713 date "2008-01-01" @default.
- W2350301713 modified "2023-09-23" @default.
- W2350301713 title "Effects of Lycopene on Oxidative Stress Induced by Intravenous Iron in Maintenance Hemodialysis Patients" @default.
- W2350301713 hasPublicationYear "2008" @default.
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