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- W2350310842 abstract "Objective To investigate the factors governing the growth and possibility that induced MSCs of adult mice to differentiate into cardiomyocytes-like in vitro.Methods Bone marrow mesenchymal stem cells were aspirated from adult SD mice,s femal bone and isolated by gradient centrifugation method.The MSCs(primary,first and third passage) were respectively treated with 5-aza for 24 h.The MSCs differentiation was observed by phase-contrast microscope,cardiac-specific antigen of the diffrentiated cells were detected by using immunohistochemistry,the expression of cardiomyocytes-specific gene was evaluated by reverse transcriptase-polymerase chain reaction(RT-PCR).Results The MSCs of primary and first passages induced by 5-aza for 4 weeks showed no positive staining for Desmin and Troponin T,but the MSCs of the third passages induced by 5-aza for 4 weeks showed postive staining for Desmin and Troponin T.Desmin positive cells were 20% and Troponin T positive cells were nearly 8%.The MSCs of the third passage induced by 5-aza for 4 weeks expressed cardiac-special genes,including ANP,GATA-4.Conclusions The MSCs cultured with 5-aza could differentiate into cardiomyocytes-like in vitro,possessing as ideal dornor cells for implantation to myocardial infarction area.(J Intervent Radiol,2006,15: 611-614)" @default.
- W2350310842 created "2016-06-24" @default.
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- W2350310842 date "2006-01-01" @default.
- W2350310842 modified "2023-09-24" @default.
- W2350310842 title "Induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes-like of adult mice in vitro" @default.
- W2350310842 hasPublicationYear "2006" @default.
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