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- W235032443 abstract "The present study investigated the role of cAMP-dependent protein kinase in modulating calcium fluxes in platelet-derived membrane vesicles enriched in the dense tubular system. Incubation of vesicles (22/sup 0/C) with 50 ..mu..M CaCl/sub 2/, 5mM phosphate and 4.5 mM ATP resulted in the accumulation of greater than 100 nmole calcium/mg protein at steady-state. If the vesicles were pretreated with protein kinase inhibitor (0.5-4.0 mg/ml) there was a marked, dose-dependent reduction in calcium uptake activity. Furthermore, addition of protein kinase inhibitor (2-12 mg/ml) at steady-state was found to cause a rapid, dose-dependent release of vesicle-accumulated calcium. Although neither peak I nor peak II cAMP-dependent protein kinase-augmented calcium accumulation during equilibration with /sup 45/Ca, incubation of vesicles with protein kinase did substantially inhibit TXA/sub 2/-induced calcium release. The ability of protein kinase inhibitor to block calcium accumulation and cause calcium release supports the notion that protein kinase plays an essential role in the calcium sequestering capacity of platelet membrane vesicles. Furthermore, the finding that protein kinase inhibits TXA/sub 2/-induced calcium release suggests that TXA/sub 2/ may act by modulation of protein kinase activity." @default.
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- W235032443 date "1986-03-01" @default.
- W235032443 modified "2023-09-24" @default.
- W235032443 title "Effects of protein kinase and protein kinase inhibitor on calcium uptake and thromboxane A/sub 2/-induced calcium release in human platelet vesicles" @default.
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