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- W2350336370 abstract "Objective To investigate the effective relationship between the MicroRNA-21(miR-21) down-regulation and the biological behaviour and PTEN expression change in gastric cancer,and the possible mechanisms of miR-21 in gastric cancer initiation and development.Methods Transfect the gastric cancer cell lines that miR-21 high expression validated previously by the research team with miR-21 inhibitor;the influence on the proliferation,apoptosis,cell cycle and migration in gastric cancer cell lines were evaluated by CCK-8 kit and Annexin-Ⅴ+PI and Transwell test;and to evaluate the change of PTEN expression after miR-21 depression in gastric cancer cell lines with Western blotting and luciferase reporter assay.Results The status of cell proliferation in vitro showed that the down-regulation of miR-21 produced an obvious inhibitive effect on the gastric cancer cell proliferation(P0.05);in vitro experiments also showed that miR-21 depression promoted apoptosis of gastric cancer cell lines of miR-21 high expression(P0.05),mainly G1/S in the cell cycle(P0.05);Transwell test showed that cell migration were notablely inhibited(P0.05);the Western blotting and luciferase reporter assay also showed that PTEN expression increased remarkably after miR-21 inhibition(P0.05).Conclusions Down-regulation of miR-21 has a strong inhibitory effect on proliferation in the gastric cancer cell lines of miR-21 high expression,and promotes apoptosis of these cells;meanwhile,depresses migration in vitro;and miR-21 down-regulation up-regulates the PTEN expression level;so PTEN may be a target gene in gastric cancer initiation and development." @default.
- W2350336370 created "2016-06-24" @default.
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- W2350336370 date "2011-01-01" @default.
- W2350336370 modified "2023-09-25" @default.
- W2350336370 title "Biological behaviour and PTEN expression change after MicroRNA-21 down-regulation in gastric cancer cells" @default.
- W2350336370 hasPublicationYear "2011" @default.
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