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- W2350343100 abstract "Objective: To investigate the expression of monocyte chemoattractant protein-1 and drug intervening in ischemia / reperfusion rat kidney.Methods:Sixty male wistar rats were randomly divided into six groups.A model of renal I/R injury was made to clamp the kidney artery.Expression of MCP-1 was measured by ELISA after reperfusion.We calculated the concentration of serum Cr,BUN that can imply the renal function.The pathologic change of renal was observed with microscope.And to observe the effect of Lovastatin on these indexes about-mentioned.Results:Expression of MCP-1 in the kidney is a little normally.We could observe the expression of MCP-1 increased at 0 hour after I/R(just ischemia) and reached a peak value at 4 hour,then dropped off subsequently.After Lovastatin was administered,the expression of MCP-1 in renal reduced(P0.01);Serum Cr,BUN decreased respectively compared with I/R 4h group(P0.05);And pathologic Paller's grade diminished(P0.01).Conclusion:The expression of MCP-1 increased in the renal ischemia/ reperfusion.These imply that MCP-1 may relate with the injury of renal;Lovastatin could decrease the MCP-1,repress the inflammatory reaction and alleviate the renal function impaired in some extent." @default.
- W2350343100 created "2016-06-24" @default.
- W2350343100 creator A5069403451 @default.
- W2350343100 date "2011-01-01" @default.
- W2350343100 modified "2023-09-23" @default.
- W2350343100 title "EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND DRUG INTERVENING IN ISCHEMIA/REPERFUSION RAT KIDNEY" @default.
- W2350343100 hasPublicationYear "2011" @default.
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