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- W2350348017 abstract "To sort the side population cells(SP cells) and non-side population cells(non-SP cells) from mouse melanoma cell line B16F10 and to investigate the mechanism of drug resistance of chemotherapy drug oncovin,the SP and Non-SP cells from B16F10 cell line were sorted by fluorescein activated cell sorter(FACS).The 50% concentration of inhibition(IC50) to oncovin was determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and the expression of ABCG2 molecule was analyzed by RT-PCR and real-time-PCR assay.It was found that the SP and non-SP cells could be sorted by FACS,and 0.96% of SP cells were detected in B16F10 cells line.The IC50 of the SP cells to oncovin was 1.26 μg/ml,whereas that of the non-SP cells was 0.37 μg/ml.This difference showed statistical significance(P0.01).The expression quantity of ABCG2 molecule in SP cells was about 6.27 times more than that in non-SP cells.These results indicate that the SP cells in mouse melanoma cell line B16F10 showed more resistance to chemotherapy drug oncovin than that in non-SP cells,and the high expression of ABCG2 molecule on the SP cells may be related to the mechanism of drug resistance." @default.
- W2350348017 created "2016-06-24" @default.
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- W2350348017 date "2011-01-01" @default.
- W2350348017 modified "2023-09-26" @default.
- W2350348017 title "Sorting of the side population cells from mouse melanoma cell line B16F10 and the preliminary analysis on the mechanism of drug resistance" @default.
- W2350348017 hasPublicationYear "2011" @default.
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