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- W2350350075 abstract "Aim To observe the hyperlipemia rabbit hemodynamic changes in the early stage of atherosclerosis by using Doppler ultrasound at different time point. Methods 60 white big-ear rabbits were divided into two groups randomly: 15 rabbits(control group) were fed with normal rabbit chow,while 45 rabbits(experiment group) were fed with high cholesterol diet.Then each group was divided into three subgroups that were fed for 4 weeks,8 weeks and 12 weeks respectively.Hemodynamic parameters(including systolic peak velocity,diastolic velocity,pulsatility index,resistent index,diameter of systole and diastole),blood lipid levels and the pathological examination were detected at each time-point. Results Levels of cholesterol and low-density lipoprotein cholesterol of experiment group increased significantly and reached peaks at 8 week,then they decreased slightly at 12 week;levels of high-density lipoprotein cholesterol decreased significantly from 8 week;triglyceride level had an obvious elevation during the experiment(P0.01).The rabbit blood vessel diameter and resistance index were with significant difference compared with control group at the same time-point(P0.01).Systolic peak velocity of 12 week,diastolic peak velocity of 4 week and 8 week,and pulsatility index of 4 week and 12 week of experiment group were all significant in statistics(P0.05).Among the subgroups Dd had no significant changes;Ds changed at 4 week and 12 week(P0.05);Vs,Vd and PI between 4 week and 12 week,8 week and 12 week were different(P0.01 or P0.001);RI between 4 week and other two time points,8 week and 12 week were different(P0.01). Conclusion Hemodynamic changes of color Doppler,that presented earlier than morphology,may dynamically detect the progression of atherosclerosis,and play an important role in early diagnosis of atherosclerosis." @default.
- W2350350075 created "2016-06-24" @default.
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- W2350350075 date "2008-01-01" @default.
- W2350350075 modified "2023-09-24" @default.
- W2350350075 title "Ultrasound Measurement and Pathological Analysis of Common Carotid Artery Hemodynamic Changes in Hyperlipoidemia Rabbits" @default.
- W2350350075 hasPublicationYear "2008" @default.
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