FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2350359249> ?p ?o ?g. }

• W2350359249 endingPage "333" @default.
• W2350359249 startingPage "327" @default.
• W2350359249 abstract "<b><i>Background:</i></b> Autoimmune liver disease (AILD) encompasses 3 main distinct clinical diseases: autoimmune hepatitis, primary biliary cholangitis (formally known as cirrhosis, PBC) and primary sclerosing cholangitis (PSC). These conditions are an important, yet under-appreciated cause of patient morbidity and mortality with ongoing unmet needs for further research and clinical advances. <b><i>Key Messages:</i></b> There is observational evidence for genetic predisposition, with all 3 conditions being more common in first degree relatives. AILD is associated with the presence of auto-antibodies and higher risks of other non-hepatic auto-immune conditions. Genetic risk association studies have identified HLA and non-HLA risk loci for the development of disease, with some HLA loci providing prognostic information. This re-enforces the concept that genetic predisposition to autoimmunity is important, likely in the context of environmental exposures. Such environmental triggers are unclear but relevant risks include smoking, drug and xenobiotic exposure as well as the complexities of the microbiome. There is evidence for a loss of immune tolerance to self-antigens playing a part in the development of these conditions. In particular the IL-2 and IL-12 regulatory pathways have been implicated in pre-disposing to an unopposed inflammatory response within the liver. Main immunological themes revolve around loss of immune tolerance leading to T-cell mediated injury, imbalance in the regulation of immune cells and defective immune response to foreign antigens. For PBC and PSC, there is then the added complexity of the consequences of cholestasis on hepato-biliary injury, immune regulation and liver fibrosis. <b><i>Conclusions:</i></b> Whilst specific disease causes and triggers are still lacking, AILD arises on the background of collective genetic and environmental risk, leading to chronic and abnormal hepato-biliary immune responses. Effective and more rational therapy will ultimately be developed when the multiple pathways to liver injury are better understood." @default.
• W2350359249 created "2016-06-24" @default.
• W2350359249 creator A5035774235 @default.
• W2350359249 creator A5041454073 @default.
• W2350359249 date "2016-01-01" @default.
• W2350359249 modified "2023-10-16" @default.
• W2350359249 title "The Pathogenesis of Autoimmune Liver Disease" @default.
• W2350359249 cites W1564080774 @default.
• W2350359249 cites W1765065804 @default.
• W2350359249 cites W1781103846 @default.
• W2350359249 cites W1969354074 @default.
• W2350359249 cites W1975137096 @default.
• W2350359249 cites W1977492688 @default.
• W2350359249 cites W1981816053 @default.
• W2350359249 cites W1981904875 @default.
• W2350359249 cites W1983779443 @default.
• W2350359249 cites W1992431640 @default.
• W2350359249 cites W1994968614 @default.
• W2350359249 cites W1996462805 @default.
• W2350359249 cites W2005913737 @default.
• W2350359249 cites W2009415077 @default.
• W2350359249 cites W2010925279 @default.
• W2350359249 cites W2022691826 @default.
• W2350359249 cites W2024447443 @default.
• W2350359249 cites W2027658027 @default.
• W2350359249 cites W2033456588 @default.
• W2350359249 cites W2040423355 @default.
• W2350359249 cites W2040560079 @default.
• W2350359249 cites W2044701146 @default.
• W2350359249 cites W2054932354 @default.
• W2350359249 cites W2059378625 @default.
• W2350359249 cites W2076639949 @default.
• W2350359249 cites W2078797149 @default.
• W2350359249 cites W2086108338 @default.
• W2350359249 cites W2087236782 @default.
• W2350359249 cites W2094995523 @default.
• W2350359249 cites W2097139406 @default.
• W2350359249 cites W2098990128 @default.
• W2350359249 cites W2099766343 @default.
• W2350359249 cites W2116397875 @default.
• W2350359249 cites W2116608035 @default.
• W2350359249 cites W2116828514 @default.
• W2350359249 cites W2124001862 @default.
• W2350359249 cites W2125566582 @default.
• W2350359249 cites W2140370242 @default.
• W2350359249 cites W2140403377 @default.
• W2350359249 cites W2143953000 @default.
• W2350359249 cites W2146711122 @default.
• W2350359249 cites W2148535164 @default.
• W2350359249 cites W2152014155 @default.
• W2350359249 cites W2153507983 @default.
• W2350359249 cites W2159992457 @default.
• W2350359249 cites W2162354645 @default.
• W2350359249 cites W2171036151 @default.
• W2350359249 cites W2395797735 @default.
• W2350359249 cites W2399530784 @default.
• W2350359249 cites W2081262992 @default.
• W2350359249 doi "https://doi.org/10.1159/000444471" @default.
• W2350359249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27170385" @default.
• W2350359249 hasPublicationYear "2016" @default.
• W2350359249 type Work @default.
• W2350359249 sameAs 2350359249 @default.
• W2350359249 citedByCount "27" @default.
• W2350359249 countsByYear W23503592492017 @default.
• W2350359249 countsByYear W23503592492018 @default.
• W2350359249 countsByYear W23503592492019 @default.
• W2350359249 countsByYear W23503592492020 @default.
• W2350359249 countsByYear W23503592492021 @default.
• W2350359249 countsByYear W23503592492022 @default.
• W2350359249 countsByYear W23503592492023 @default.
• W2350359249 crossrefType "journal-article" @default.
• W2350359249 hasAuthorship W2350359249A5035774235 @default.
• W2350359249 hasAuthorship W2350359249A5041454073 @default.
• W2350359249 hasBestOaLocation W23503592492 @default.
• W2350359249 hasConcept C126322002 @default.
• W2350359249 hasConcept C147483822 @default.
• W2350359249 hasConcept C151730666 @default.
• W2350359249 hasConcept C159654299 @default.
• W2350359249 hasConcept C188280979 @default.
• W2350359249 hasConcept C203014093 @default.
• W2350359249 hasConcept C2776029263 @default.
• W2350359249 hasConcept C2776090121 @default.
• W2350359249 hasConcept C2777075537 @default.
• W2350359249 hasConcept C2777203481 @default.
• W2350359249 hasConcept C2777702733 @default.
• W2350359249 hasConcept C2778296632 @default.
• W2350359249 hasConcept C2779075594 @default.
• W2350359249 hasConcept C2779134260 @default.
• W2350359249 hasConcept C2779343474 @default.
• W2350359249 hasConcept C2779609443 @default.
• W2350359249 hasConcept C2780130043 @default.
• W2350359249 hasConcept C2780366471 @default.
• W2350359249 hasConcept C2780615123 @default.
• W2350359249 hasConcept C2911091166 @default.
• W2350359249 hasConcept C67636389 @default.
• W2350359249 hasConcept C71924100 @default.
• W2350359249 hasConcept C79484868 @default.
• W2350359249 hasConcept C86803240 @default.

• next