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- W2350366543 abstract "Objective:To investigate the efficacy and safety of glipizide GITS combined with bedtime insulin glargine or bedtime neutral protamine Hagedorn(NPH)insulin in patients with type 2 diabetes.Methods:471 cases with inadequate glycemia control by sulfonylurea and/or other oral agents were randomized in two groups(3:1).In the Glarine group,patients were given Clipizide GITS 5 mg every morning and injection of Glargine at bedtime daily,while patients in the NPH group were given Clipizide GITS 5 mg every morning and injection of NPH at bedtime daily.The dosage of insulin was adjusted by FBG level,seeking a target of FBG6.7mmol/L,and the treatment lasted for 12 weeks and 5 visits.Results:The treatment groups showed similar improvements in HbA1c from baseline to end point,and The mean change in HbA1c from baseline to end point was similar in the insulin glargine group(0.96%)and the NPH group(1.25%).Mean daily glucose profile were similar in the 2 groups.The treatments were associated with similar reductions in fasting glucose levels.Overall, mild symptomatic hypoglycemia was similar in insulin glargine subjects(21.25%)and NPH insulin subjects(28.81%),but the incidence of nocturnal hypoglycemia in the Glargine group was significantly lower than that in the NPH group(P=0.0334). Mean daily dosages of glargine and NPH at the end point were 19.21 IU and 18.68IU,respectively.Conclusion:In patients with type 2 diabetes,once-daily bedtime insulin glargine is as effective as once-daily NPH in improving and maintaining glycemic control when combined with Glipizide GITs.In addition,insulin glargine demonstrates a lower risk of nocturnal hypoglycemia and similar weight gain compared with NPH insulin." @default.
- W2350366543 created "2016-06-24" @default.
- W2350366543 creator A5083581289 @default.
- W2350366543 date "2006-01-01" @default.
- W2350366543 modified "2023-09-23" @default.
- W2350366543 title "A multicenter,randomized,open-labelled,NPH parallel controlled study to evaluate the efficacy and safety of once daily injection of glargine combined with glipizide GITS in the treatment of poor-controled type II diabetes mellitus" @default.
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