Matches in SemOpenAlex for { <https://semopenalex.org/work/W2350393669> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2350393669 abstract "OBJECTIVE To develop and optimize the formulation of naltrexone implants (NTX IMPs) which would be effective over one month period.METHODS An L 16 (4 5) orthogonal design was used to investigat the effects of three formulation variables [the dosage of implants,the content of basic additive,Mg(OH) 2,and the content of poly lactic acid on in vitro drug release profiles.The in vitro release percentages in 1,5,13,21 and 30 days were determined as the response parameters.The correlations between variables and response parameters were calculated by multiple linear regression,and the optimal region for the implant formulation was identified in a superimposed contour plot.RESULTS The quantitative relationships between three formulation variables and in vitro release percentages in 1,5,13,21 and 30 days were obtained.The optimized NTX IMPs which have the desired in vitro drug release characteristics were obtained from the superimposed contour plot.CONCLUSION The desired NTX implants were developed by means of a superimposed contour plot.Such method can be used in optimizing of multiple response parameters." @default.
- W2350393669 created "2016-06-24" @default.
- W2350393669 creator A5074639267 @default.
- W2350393669 date "2000-01-01" @default.
- W2350393669 modified "2023-09-25" @default.
- W2350393669 title "In vitro optimization of naltrexone implants" @default.
- W2350393669 hasPublicationYear "2000" @default.
- W2350393669 type Work @default.
- W2350393669 sameAs 2350393669 @default.
- W2350393669 citedByCount "0" @default.
- W2350393669 crossrefType "journal-article" @default.
- W2350393669 hasAuthorship W2350393669A5074639267 @default.
- W2350393669 hasConcept C105795698 @default.
- W2350393669 hasConcept C136229726 @default.
- W2350393669 hasConcept C141071460 @default.
- W2350393669 hasConcept C167651023 @default.
- W2350393669 hasConcept C170493617 @default.
- W2350393669 hasConcept C185592680 @default.
- W2350393669 hasConcept C186060115 @default.
- W2350393669 hasConcept C202751555 @default.
- W2350393669 hasConcept C2777972943 @default.
- W2350393669 hasConcept C2781063702 @default.
- W2350393669 hasConcept C2781411149 @default.
- W2350393669 hasConcept C33923547 @default.
- W2350393669 hasConcept C48921125 @default.
- W2350393669 hasConcept C55493867 @default.
- W2350393669 hasConcept C71924100 @default.
- W2350393669 hasConcept C86803240 @default.
- W2350393669 hasConceptScore W2350393669C105795698 @default.
- W2350393669 hasConceptScore W2350393669C136229726 @default.
- W2350393669 hasConceptScore W2350393669C141071460 @default.
- W2350393669 hasConceptScore W2350393669C167651023 @default.
- W2350393669 hasConceptScore W2350393669C170493617 @default.
- W2350393669 hasConceptScore W2350393669C185592680 @default.
- W2350393669 hasConceptScore W2350393669C186060115 @default.
- W2350393669 hasConceptScore W2350393669C202751555 @default.
- W2350393669 hasConceptScore W2350393669C2777972943 @default.
- W2350393669 hasConceptScore W2350393669C2781063702 @default.
- W2350393669 hasConceptScore W2350393669C2781411149 @default.
- W2350393669 hasConceptScore W2350393669C33923547 @default.
- W2350393669 hasConceptScore W2350393669C48921125 @default.
- W2350393669 hasConceptScore W2350393669C55493867 @default.
- W2350393669 hasConceptScore W2350393669C71924100 @default.
- W2350393669 hasConceptScore W2350393669C86803240 @default.
- W2350393669 hasLocation W23503936691 @default.
- W2350393669 hasOpenAccess W2350393669 @default.
- W2350393669 hasPrimaryLocation W23503936691 @default.
- W2350393669 hasRelatedWork W1973705920 @default.
- W2350393669 hasRelatedWork W1987558091 @default.
- W2350393669 hasRelatedWork W2037841105 @default.
- W2350393669 hasRelatedWork W2071980979 @default.
- W2350393669 hasRelatedWork W2113344068 @default.
- W2350393669 hasRelatedWork W2114340344 @default.
- W2350393669 hasRelatedWork W2131565520 @default.
- W2350393669 hasRelatedWork W2168319407 @default.
- W2350393669 hasRelatedWork W2181374120 @default.
- W2350393669 hasRelatedWork W2186206888 @default.
- W2350393669 hasRelatedWork W2262996952 @default.
- W2350393669 hasRelatedWork W2352191111 @default.
- W2350393669 hasRelatedWork W2368466748 @default.
- W2350393669 hasRelatedWork W2369947406 @default.
- W2350393669 hasRelatedWork W2379352606 @default.
- W2350393669 hasRelatedWork W2744163234 @default.
- W2350393669 hasRelatedWork W2963921475 @default.
- W2350393669 hasRelatedWork W2184196440 @default.
- W2350393669 hasRelatedWork W2188113534 @default.
- W2350393669 hasRelatedWork W2326880854 @default.
- W2350393669 isParatext "false" @default.
- W2350393669 isRetracted "false" @default.
- W2350393669 magId "2350393669" @default.
- W2350393669 workType "article" @default.