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- W2350405506 abstract "Objective To observe the change both in ear weight and in leukocyte migration inhibitory factor (LMIF) activity during conditioned immunosuppressive response, and to analyze the mediator produced in conditioned mouse. Methods Camphor odor and intraperitoneal (ip) injection of cyclophosphamide (CY) were used as conditioned and unconditio ned stimulus, respectively. Dinitrochlorobenzene (DNCB) was smeared on mouse abdominal skin to sensitize the animal. Five days later, DNCB was smeared on mouse left ear for the challenge of delayed type hypersensitivity (DTH) response. Weight ratio of left/right ear and LMIF activity were used as the index of DTH response. Results In the DTH group, weight ratio of left/right ears and LMIF activity increased as compared with DTH (-) group, indicating that a DTH was induced. In the unconditioned group, weight ratio of left/right ear and LMIF activity were much lower than that in the DTH group, indicating that DTH was inhibited by CY. In the conditioned group, weight ratio of left/right ear and LMIF activity were also statistically lower than that in the DTH group but there was no statistical difference between unconditioned and conditioned group, indicating that a conditioned response happened. It also showed that when CR serum was injected into normal mice, DTH response was suppressed significantly. If CR serum was dialyzed against a membrane with a 10 000 molecular weight cut off, the suppressive activity was abolished. Conclusion A new animal model of conditioned immunosuppression both on the reaction of ear skin and on the LMIF activity was built up. A compound(s) with molecular weight less than 10 000 was generated in CR serum, which might function to mediate the conditioned immunosuppressive response." @default.
- W2350405506 created "2016-06-24" @default.
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- W2350405506 date "2000-01-01" @default.
- W2350405506 modified "2023-09-25" @default.
- W2350405506 title "Preliminary Studies of Conditioned Immunosuppressive Effect of Cyclophosphamide on Delayed Type Hypersensitivity Response" @default.
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