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- W2350432762 abstract "Objective To study the immuno-protective efficacy of IFN-γ combined with TNF against mycobacterium tuberculosis infected mice.Methods The mice were treated with IFN-γ and /or TNF for 5 days postinfection challenged with H(37)RV by their tail veins.Time of fifty percent death(T(50)) and mortality rate within 35 days were investigated.The numbers of viable bacteria in spleen were counted.The level of IFN-γ and IL-4 in ConA-induced spleen cell cultural supernatant were detected with enzyme linked immunosorbent assay(ELISA) method.The level of nitric oxide(NO) in macrophage cultural supernatant was measured using Griess reagent.Results The combination of IFN-γ with TNF group prolonged T(50),decreased mortality rate within 35 days,diminished the numbers of viable bacteria in spleen,promoted the level of IFN-γ and reduced the level of IL-4 secreted by spleen cells,enhanced the production of NO secreted by MΦ.There was significant difference compared with infection control group(P0.01).Conclusion The combination of IFN-γ with TNF could induce NO production by MΦ,promote development of Th1 cell response,inhibit Th2 cell response,modulate Th1 and Th2 cytokine balance,which suggested that could enhance the host defense against the infection with H(37)RV." @default.
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- W2350432762 date "2008-01-01" @default.
- W2350432762 modified "2023-09-28" @default.
- W2350432762 title "Immuno-protection Efficacy of Cytokines Against TB in Mice" @default.
- W2350432762 hasPublicationYear "2008" @default.
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