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- W2350437057 abstract "Objective:To investigate the effects of aripiprazole on late-onset schizophrenia and cognitive function in comparison with risperidone.Methods:Forty-five patients with late-onset schizo- phrenia were randomly divided into aripiprazole(n=21)and risperidone(n=24)groups.The dose of aripiprazole was 10～30 mg·d~(-1),and risperidone was 3～4 mg·d~(-1).Positive and negative symptom scales(PANSS),and treatment side-effect scales(TESS)were used to assess the efficacy and safety. Event-related potential was detected before and after treatment.Results:There was no significant differ- ence in the total efficient rate between aripiprazole(71.4%)and risperidone(75.0%)groups(P0.05).Comparing to the healthy subjects,there were both a significant difference in the event-related potentials(P0.05)in aripiprazole and risperidone groups before treatment,but no significant differ- ence was found after treatment.TESS was also not significantly different between 2 groups.Conclusion: The effects of aripiprazole and risperidone on late-onset schizophrenia are not different.Both drugs have minor side-effects and little effect on cognitive function." @default.
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- W2350437057 date "2007-01-01" @default.
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- W2350437057 title "Effect of aripiprazole on late-onset schizophrenia and cognitive function" @default.
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