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- W2350463648 abstract "Objective: To examine the expression of Klf4,p21,p53,APC,and CyclinD-1 in breast invasive ductal carcinoma(BIDC),and to explore the relationship between the expression and clinicopathological features of this carcinoma.Methods: Immunohistochemical SP method was used to detect the expression of Klf4,p21,p53,APC,and CyclinD-1 protein in BIDC(with or without lymph node metastasis),and benign breast lesions(fiber adenosis or fiber adenoma).Results:(1) The expression levels of KLF4 protein in BIDC increased with the increase of histological grade,TNM staging,tumor size and patient age(P0.05);The expression levels of p21 were higher in patients with lymph node metastasis than those in patients without lymph node metastasis(P0.05);The APC expression level increased with the increase of TNM stage(P0.05);(2) The expression of KLF4 were positively correlated with those of p21(P0.01);(3) The levels of KLF4,p53,p21 and CyclinD-1 were obviously higher and the expression of APC was obviously lower in BIDC than those in benign breast lesions(P0.05).Conclusions: The expression levels of Klf4,p21,and APC in BIDC are correlated with its clinicopathologic features." @default.
- W2350463648 created "2016-06-24" @default.
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- W2350463648 date "2013-01-01" @default.
- W2350463648 modified "2023-09-28" @default.
- W2350463648 title "The Expression of KLF4,p21,p53,APC and CyclinD-1 in Breast Invasive Ductal Carcinoma and Its Significance" @default.
- W2350463648 hasPublicationYear "2013" @default.
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