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- W2350464038 abstract "AIM To investigate the influence of tranilast on cell cycle modulatory factors and proliferation response of vascular smooth muscle cell after balloon angioplasty.METHODS Aortic tissues were harvested at day 14 after injury and HE staining and immunohistochemistry staining were used to measure the protein expressions of cell cycle modulatory factors p27.Flow Cytometry(FCM) was applied to determine the cell cycle of the neointima.RESULTS ① Neointima formation was apparent in the arteries from the operation group and was reduced much more in the tranilast group [(0.32±0.05) mm~(2) vs((0.14)±(0.01)) mm~(2),P0.01)].②Immunohistochemistry staining revealed that p27 protein expressions were low in the neointima of the model group and were significantly increased by tranilast(20.8±1.7 vs 10.5±(0.7),P0.01).③ FCM showed that in the model group,the percentage of S phase of smooth muscle cells was high but declined in the tranilast group [(27.5±1.1)% vs(13.5±1.5)%,P(0.01)].(CONCLUSION) Tranilast surpresses neointima formation after artery injury by up-regulation of p27." @default.
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- W2350464038 date "2006-01-01" @default.
- W2350464038 modified "2023-09-26" @default.
- W2350464038 title "Tranilast in preventing restenosis after rat thoracic aorta balloon injury" @default.
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