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- W2350480804 abstract "Objective To investigate the effect of metformin on inflammatory cytokines of saturated fatty acid( SFA)-induced RAW264. 7 macrophage. Methods RAW264. 7 cells were treated with SFA to establish inflammatory model in vitro. Macrophages were divided into normal control group,SFA-treated group,metformin + SFAtreated group and AMPK inhibitor Compound C + metformin + SFA-treated group. RT-PCR was used to detect mRNA expression levels of TNF-α and IL-6. ELISA was used to detect secretion levels of TNF-α and IL-6 in cell supernatants. Western blot was used to analyze phosphorylation level of AMP-activated protein kinase. Results Compared to normal control group,both mRNA expression and protein secretion of TNF-α and IL-6 increased in SFA-treated group( P 0. 05). Compared to SFA-treated group,both mRNA expression and protein secretion of TNF-α and IL-6 decreased in metformin + SFA-treated group( P 0. 05),and AMPK phosphorylation level was significantly enhanced( P 0. 05). Compared to metformin + SFA treated-group,mRNA expression and proteinsecretion of TNF-α and IL-6 increased,and AMPK phosphorylation level deceased in Compound C + metformin +SFA-treated group( P 0. 05). Conclusions Metformin suppresses secretion of inflammatory cytokines TNF-αand IL-6 in saturated fatty acid-induced RAW264. 7 macrophage via activation of AMPK." @default.
- W2350480804 created "2016-06-24" @default.
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- W2350480804 date "2015-01-01" @default.
- W2350480804 modified "2023-09-25" @default.
- W2350480804 title "Metformin alleviates saturated fatty acid-induced inflammation in RAW264.7 macrophage via activating AMPK pathway" @default.
- W2350480804 hasPublicationYear "2015" @default.
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