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- W2350486550 abstract "OBJECTIVE:To detect the distribution of CD4+IL-9+(Th9)lymphocyte in immune microenvironment of colorectal cancer(CRC)and analyze its relation with clinical pathology.METHODS:Forty-five patients with CRC who underwent surgery for the first time from 2013-06-05to 2013-10-10in First Affiliated Hospital of Guangxi Medical University were enrolled,tumor and relevant para-carcinoma tissue,pre or post-operative peripheral blood(PB)of these patients,and PB from 15healthy volunteers were detected for the proportion of Th9,Th1,Th2in CD4+lymphocyte by flow cytometry(FCM).Clinic pathologic data like sexy,age,nation,Ducks stage,tumor size,metastasis of lymphocyte,lever of CEA and AFP was recorded. Tumor tissue of another 5patients with CRC underwent FCM for analysis of expression of CD45RO/CD45RA.RESULTS:The proportion of Th9in tumor tissue was(1.12±0.33)%,which was significantly higher than that in para-carcinoma tissue(0.85±0.29)%and PB(0.65±0.27)%,respectively(P0.05).Th9in tumor tissue showed high expression of CD45RO(85.23±5.91)%and low expression CD45RA(18.23±6.78)%.The poroportion of Th9in PB before operation was higher than that after operation(0.47±0.24)%(P=0.001 2).Th9lymphocyte was concerned with Ducks stage(P0.05),while it had nothing to do with other factors,there was no significant correlation between the proportion of Th9in tumor tissue and Th1(r=-0.140,P=0.360),while negative correlation existed between Th9and Th2(r=-0.65,P0.001).CONCLUSION:There is enrichment phenomenon of Th9in the immune microenvironment of CRC,Th9is related to the progression of CRC and may take part in regulating the immune microenvironment of CRC and play an important role in the progress of CRC." @default.
- W2350486550 created "2016-06-24" @default.
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- W2350486550 date "2014-01-01" @default.
- W2350486550 modified "2023-09-26" @default.
- W2350486550 title "Distribution and clinical significance of CD4~+ IL-9~+ lymphocyte in immune microenvironment of colorectal cancer" @default.
- W2350486550 hasPublicationYear "2014" @default.
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