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- W2350487304 abstract "BACKGROUND OBJECTIVE: It was proved that nuclear factor κB (NF-κB) and its inhibitor protein κB (I-κB) played critical roles in regulating the expression of proapoptotic genes, and NF-κB is overexpressed in some tumors and related with tumorigenesis. However, the expression of NF-κB and I-κB in cervical cancer and its correlation to human papillomavirus (HPV) infection have not been reported yet. This study was to explore the correlation of the expression of NF-κB, I-κB, and Bcl-2 in cervical cancer to human papillomavirus (HPV) infection. METHODS: The expression of NF-κB, I-κB, and Bcl-2 were detected by immunohistochemistry in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. HPV DNA was detected by polymerase chain reaction (PCR). RESULTS: The positive rates of NF-κB and Bcl-2 were significantly higher in cervical cancer than in normal cervical tissue (60.9% vs. 23.1%, 52.2% vs. 0.0%, P0.01). The positive rate of I-κB was significantly lower in cervical cancer than in normal cervical tissue (30.4% vs. 57.7%, P0.05). The expression of NF-κB was closely related to Bcl-2 (P0.05). The positive rate of NF-κB was significantly higher in HPV DNA-positive cervical cancer than in HPV DNA-negative cervical cancer (81.3% vs. 35.7%, P0.05), but the positive rates of I-κB and Bcl-2 between these 2 groups had no significant difference (P0.05). CONCLUSION: The high expression of NF-κB and Bcl-2 and the low expression of I-κB may be related to cervical carcinogenesis, and NF-κB expression may be related to HPV infection." @default.
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- W2350487304 date "2005-11-01" @default.
- W2350487304 modified "2023-09-23" @default.
- W2350487304 title "[Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection]." @default.
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