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- W2350535737 abstract "Innate immunity initiates immediate defense mechanisms on the basis of non-clonal recognition of microbial components.By the use of germ-line encoded PRRs,the innate immune system is capable of detecting invariant pathogen motifs termed pathogen-associated molecular patterns(PAMPS) that are distinct from host encoded proteins or products released from dying cells.Based on ligand recognition,all of these receptors depend upon the interaction of specific bridging proteins to initiate a cascade that results in signaling events.The PRR signaling eventually activates the expression of multiple host immune and pro-inflammatory genes and direct an immune response to the detected pathogen.The PRRs currently are classified into five major groups: the C-type lectins,Toll-like receptors(TLRs),RIG I-like receptors(RLRs),NOD-like receptors(NLRs),and the recently designated absent in melanoma(AIM)-like receptors(ALRs).Recently,the emergence of genomics research and draft genome sequences of five bony fish species resulted in the discovery of many PRR genes in teleosts.The ligand specificity of some PRRs and their related signaling cascades have been clarifying.In this paper,recent research progress on fish TLRs,RLRs and NLRs has been reviewed." @default.
- W2350535737 created "2016-06-24" @default.
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- W2350535737 date "2012-01-01" @default.
- W2350535737 modified "2023-09-25" @default.
- W2350535737 title "Research progress on pattern-recognition receptors in fish" @default.
- W2350535737 hasPublicationYear "2012" @default.
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