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- W2350544250 abstract "Objective To study the relationship between Schistosoma japonicum soluble egg antigen(SEA) and asthma and the effects of SEA on CD4+CD25+ regulatory T cells(CD4+CD25+Treg) and expression of the Foxp3 gene.Methods BALB/C mice were each injected with 50 μg SEA peritoneally and through the foot pad once a week for 4 weeks.In the control group,all injections were with normal saline.Then asthma was induced with ovalbumin(OVA) in all mice.After mice were sacrificed,the lungs were subjected to pathologic examination;the bronchoalveolar lavage fluid(BALF) was collected and different cells were classified and counted after smearing and staining.Spleen cells were separated and the percentage of CD4+CD25+Treg out of total CD4+ T cells was determined using flow cytometry.Total spleen RNA was prepared and synthesized into cDNA through reverse transcription;cDNA was subjected to PCR amplification to determine the level of Foxp3 mRNA expression.Results Mild pulmonary inflammation was observed in the SEA immunization group,whereas severe inflammation was observed in the control group.Staining of the BALF revealed that the SEA immunization group had a much lower BALF cell density than did the control group.In the SEA immunization group,the percentage of eosinophils out of total cells was(2.22±1.52)% while it was(19.93±4.08)% in the control group.The difference between the 2 groups was statistically significant(P0.05).Flow cytometry revealed that the percentage of CD4+CD25+Treg out of total CD4+ T cells was(32.24±2.19)% in the SEA immunization group while it was(27.41±2.87)% in the control group.The difference between the 2 groups was statistically significant(P0.05).The level of Foxp3 mRNA expression was higher than that in the control group as well.Conclusion SEA inhibits the development of asthma to some extent and it seems influence immune regulation through its effect on CD4+CD25+Treg." @default.
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- W2350544250 date "2011-01-01" @default.
- W2350544250 modified "2023-09-23" @default.
- W2350544250 title "A study of the effects of Schistosoma japonicum soluble egg antigen on CD4~+ CD25~+ regulatory T cells in patients with asthma" @default.
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