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- W2350546917 abstract "Objective To explore the relationship of NF-кB's activity and systemic inflammatory response syndrome(SIRS) induced by open abdominal injury and seawater immersion in rats.MethodsRat models with open abdominal injury and seawater immersion were established and SIRS was induced.The levels of TNF-α and IL-6 were examined by enzyme-linked immunosorbent assay(ELISA).NF-кB activity in PBL and intestinal tissues were examined by immunohistochemical staining.ResultsSIRS was observed after 1hour of seawater immersion of rats with abdominal injuries;the levels of TNF-α and IL-6 increased;the positive rate of NF-кB's expression in PBL and intestinal tissue increased significantly,which had statistical significance compared with the control groups(P0.05 or P0.01).ConclusionOpen abdominal injury and seawater immersion can cause SIRS in rats.NF-кB,TNF-α and IL-6 involve in the occurrence and development of SIRS.The activation of NF-кB mediates the release of TNF-α and IL-6 and might play a central role in SIRS." @default.
- W2350546917 created "2016-06-24" @default.
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- W2350546917 date "2009-01-01" @default.
- W2350546917 modified "2023-09-23" @default.
- W2350546917 title "Relationship of nuclear factor kappa B and systemic inflammatory response syndrome (SIRS) caused by open abdominal injury and seawater immersion in rats" @default.
- W2350546917 hasPublicationYear "2009" @default.
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