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- W2350548852 abstract "Objective To study the preventive effects of ACEI-CPT on Wistar rats with ARDS induced by oleic acid,and to explor the possible mechanism.Methods 36 healthy Wistar rats were randomly divided into three groups:the CPT treatment group,the ARDS group,and the Sham operated group.The rats were killed 3h or 6h after operations respectively.The blood in the left ventricle was taken out completely to examine the contents of ACE、AⅡ and ET-1.The left and right lung tissues were weighed.The right part was desiccated and weighed again,the left part was prepared to be observed under microscope and electronic microscope.Results The water content in lung and the blood ACE 、AⅡ、ET-1 contents in ARDS group were markedly increased when contrasted with the sham operation group(P0.05),and the difference between the CPT treatment group and the ARDS group was also quite significant(P0.05).The correlation between levels of ACE、AⅡ、ET-1 and the corresponding lung coefficient was significant(P0.05).Conclusion In the early stage of ARDS,the blood ACE、AⅡ、ET-1 contents correlate with lung coefficients.The administration of ihbitior of angiotensin to convert enzyme captopril can inhibit the increase of their blood ACE,AⅡ,ET-1 levels.ACEI-CPT have certain good protective effects on rats with ARDS." @default.
- W2350548852 created "2016-06-24" @default.
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- W2350548852 date "2005-01-01" @default.
- W2350548852 modified "2023-09-23" @default.
- W2350548852 title "AN EXPERIMENTAL STUDY OF THE PREVETATIVE EFFECT OF ACEI ON CHEMICAL-INDUCED ARDS IN RATS" @default.
- W2350548852 hasPublicationYear "2005" @default.
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