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- W2350549013 abstract "Objective:To investigate the neuroprotective effect and mechanism of Di Huang Yin Zi(DHYZ) on AD.Methods:To investigate the expression of ChAT and tau of PC12 in each group by using cellular immunity.Results:1.The expression of ChAT in the group of PC12 induced by Aβ25-35 was significantly lower than that of control group(P0.01),and after adding CSF DHYZ,the expression of ChAT was enhanced(P0.05 or P0.01).There was no difference between Chinese medicine group(CMG) and the Aricept group(P0.05).2.The expression of tau in the group of PC12 induced by Aβ25-35 was significantly heigher than that of control group(P0.01),and after adding CSF DHYZ,the expression of tau was decreased(P0.01) in a dose-dependent pattern.The high-does CMG and the moderate-dose CMG were better than that of other groups,and better than the Aricept group with a singificant difference(P0.01).Conclusion:DHYZ could obviously improve the expression of ChAT of PC12 induced by Aβ25-35,and significantly decease the expression of canaliculus-associated protein-tau of PC12 induced by Aβ25-35.So DHYZ can protect the neurons,prevent and treat AD." @default.
- W2350549013 created "2016-06-24" @default.
- W2350549013 creator A5071941735 @default.
- W2350549013 date "2011-01-01" @default.
- W2350549013 modified "2023-09-23" @default.
- W2350549013 title "The Experimental Research on the Effect of DHYZ on Neuro-protection of Alzheimer Disease" @default.
- W2350549013 hasPublicationYear "2011" @default.
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