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- W2350557364 abstract "Objective: To investigate the anti-inflammation effects of rapamycin versus paclitaxel coated stents on interleukin-1βinduced coronary stenosis in pigs. Methods: Fourteen male domestic young pigs (2 to 3 months, 25 to 30 kg)were operated on via thoracotomy. The mid left anterior descending(LAD)and left circumflex coronary artery(LCx) were respectively undermined 10 mm segment and aseptically wrapped with cotton mesh soaked in IL-1β5 ug. Two weeks later, the animals were anesthetized and quantitative coronary arteriography ( QCA ) was performed. The stented coronary artery segments were processed for plastic embedding and HE staining. The intimal areas of the coronary artery were calculated. The expression of MCP-1, TNFα, P-selectin, and VCAM-1 mRNA on the wall of stented vessels were detected by RT-PCR method. Results: The QCA results showed severe stenosis at IL-1βtreated LAD and LCx sites. All the stenosis sites were randomized into 3 groups: sirolimus eluting stent group (SES,n =7) , paclitaxel eluting stent group (PES,n =9) and bare-metal Yinyi?stent (BMS) group (BMS, n =8). Four weeks after PCI, follow-up QCA was performed again. The results showed that compared with BMS, both sirolimus and paclitaxel coated stents reduced a one-month angiographic late lumen loss(LLL) within the stent and the lesion. A significant neointimal hyperplasia in BMS was found. The area of neointimal hyperplasia was markedly inhibited by drug eluting stents (SES 11. 6±1. 7, PES 27. 2±1. 6% vs BMS 76. 2±1. 3% ,P 0. 01). The mRNA level of MCP-1, TNFα, P-selectin, and VCAM-1 were markedly decreased in SES group compared with PES and BMS groups. Conclusion: Both SES and PES reduced a one-month angiographic LLL and neointima hyperplasia in young pigs. SES was better than PES in LLL The possible anti-hyperplasia mechanisms of SES in this ISR model may be partly via anti-inflammation effects of SES, which were not found in PES group." @default.
- W2350557364 created "2016-06-24" @default.
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- W2350557364 date "2006-01-01" @default.
- W2350557364 modified "2023-09-26" @default.
- W2350557364 title "Quantitative Angiographic Results of Sirolimus and Paclitaxel Coated Stents on Inflammatory Coronary Lesions in Pigs" @default.
- W2350557364 hasPublicationYear "2006" @default.
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