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- W2350558049 abstract "Aim:To study the effects of proanthocyanidins on the expression of iNOS gene in peritoneal macrophages of rats with adjuvant arthritis(AA).Methods:The adjuvant arthritis model of rats was induced by the application of complete Freunds adjuvant.Contents of NO in paws of rats were measured by enzyme reduction of nitrate.The expression of iNOS mRNA and protein in rat′s peritoneal macrophages was analyzed by RT-PCR and Western blot.Contents of TNF-α and IL-1β in the rat blood serum were measured by ELISA.Results:Proanthocyanidins significantly suppressed the contents of NO in edema paws as well as serum levels of TNF-α and IL-1β of rats suffered from adjuvant arthritis.Proanthocyanidins also inhibited the expression of iNOS mRNA and protein in peritoneal macrophages of AA rats.Conclusion:The mechanisms of proanthocyanidins against adjuvant arthritis in rats is likely related to inhibition of the release of NO TNF-α and IL-1β as well as the expression of iNOS gene." @default.
- W2350558049 created "2016-06-24" @default.
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- W2350558049 date "2006-01-01" @default.
- W2350558049 modified "2023-09-27" @default.
- W2350558049 title "Effects of proanthocyanidins on the expression of induced nitric oxide synthase(iNOS) gene in peritoneal macrophages of rats with adjuvant arthritis" @default.
- W2350558049 hasPublicationYear "2006" @default.
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