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- W2350559494 abstract "Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) with a distinct biology and clinical presentation. The vast majority of cases are characterized by a translocation that fuses the promyelocytic leukemia gene (PML) on chromosome 15 with a gene encoding a retinoic acid receptor (RARα) on chromosome 17. As a single agent, all-trans retinoic acid (ATRA) has produced complete remissions in up to 90% of patients, and the use of ATRA in combination with chemotherapy has significantly reduced relapse rates and improved survival. Similarly, arsenic trioxide (ATO) has produced remission in up to 90% of patients with relapsed APL. This article examined the molecular pathogenesis as it relates to the diagnosis and monitoring of APL and review current therapeutic approaches." @default.
- W2350559494 created "2016-06-24" @default.
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- W2350559494 date "2009-01-01" @default.
- W2350559494 modified "2023-09-27" @default.
- W2350559494 title "Molecular Pathogenesis and Current Therapeutic Approaches of APL" @default.
- W2350559494 hasPublicationYear "2009" @default.
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