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- W2350563813 abstract "Objective To explore the therapeutic effect and probable mechanism of olfactory ensheathing cell (OEC) transplantation for Friedreich's ataxia patients.Methods Eleven patients with Friedreich's ataxia were treated by OEC transplantation from August 2005 to May 2009.OECs were implanted into the spinal cord involved region in 4 patients and the corona radiata of the frontal lobe (key point for neural network restoration,KPNNR) bilaterally in 7 patients.The neurological function was assessed before and 2 to 4 weeks after operation though International Cooperative Ataxia Rating Scale (ICARS) by World Federation of Neurology.Results ICARS score decreased from pre-operative 50.73±21.80 points to post-operative 45.27±23.99(P=0.004).There were no significant difference in two groups which transplanted into spinal cord and brain (P=0.104).All patients achieved neurological function amelioration to different degrees,which including walking ability,gaits and standing.Of them,8 patients were followed up for over six months.Balance and walking ability keep improving in 4 patients.The follow-up MRI did not reveal any development of tumor,hemorrhage,edema,cyst formation,infection or disruption of the neural structure in and surrounding these transplant sites.Four patients keep stable.No complications occurred within the period of 2 to 4 weeks after surgery and long term follow-up.Conclusions OEC transplantation appears to be benefit for patient with Friedreich's ataxia and no remarkable difference between two groups (intracranial and intraspinal).KPNNR may be the site which can dual-directionally regulate the neural signals among neural network of cerebra,cerebellum and spinal cord followed cell transplant." @default.
- W2350563813 created "2016-06-24" @default.
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- W2350563813 date "2011-01-01" @default.
- W2350563813 modified "2023-09-28" @default.
- W2350563813 title "Olfactory ensheathing cell therapy for treating Friedreich ataxia" @default.
- W2350563813 hasPublicationYear "2011" @default.
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