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- W2350571881 abstract "High abundance and tissue-specific gene expression are important for gene therapy and preparation of transgenic animals.Cre-LoxP system is effective to improve transcriptional activity of tissue-specific promoter.However,it is not known if the Cre-LoxP system affects the tissue-specific expression regulated by the specific promoter..In this study,intestinal mucin 2 promoter was used to regulate the Cre recombinase expression base on Cre-LoxP system.Then luciferase activity was detected after transfection.The results showed that Cre-LoxP system increased the expression of mucin 2 promoter-mediated target genes(6-fold) in intestinal cells.However,cell-specific tests showed that the system decreased the specificity of mucin 2 promoter.The results suggest that the use of Cre-LoxP system requires higher specificity of the promoter although the system can significantly improve the weak promoter activity." @default.
- W2350571881 created "2016-06-24" @default.
- W2350571881 creator A5071351579 @default.
- W2350571881 date "2012-01-01" @default.
- W2350571881 modified "2023-09-26" @default.
- W2350571881 title "Cre-LoxP System Regulates the Activity and Specificity of Mucin 2 Promoter" @default.
- W2350571881 hasPublicationYear "2012" @default.
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