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- W2350578093 abstract "Objective To evaluate the relationship between the uptake of ~ 99 Tc~m -MIBI and the expression of P-glycoprotein (P-gp) and multidrug resistance related protein (MRP) in primary lung cancer. Methods SPECT imaging was performed at 30 min and 180 min after injecting ~ 99 Tc~m -MIBI in twenty-five patients with primary lung cancer. The uptake ratio of the lesion and the contralateral normal lung was obtained by early imaging (early uptake ratio, EUR) as well as delayed imaging (delayed uptake ratio, DUR) at the region of interest. The retention index (RI) was calculated as follows: RI=(DUR-EUR)/EUR. The ratio was compared with the level of P-gp and MRP expression detected by immunohistochemical analyses respectively. Results ① The positive rate of ~ 99 Tc~m MIBI was 92.00% in early imaging and 80.00% in delayed imaging. The EUR and DUR of ~ 99 Tc~m MIBI was (1.46±0.42) and (1.45±0.39) respectively. 13 cases were RI0, and 12 cases were RI0. ② The positive expressions of P-gp and MRP were observed in 13 (52.00%) cases and 4 (16.00%) cases respectively. ③ There was significant difference in RI between P-gp(-) and P-gp(+) and correlation between RI and P-gp levels. There was no significant difference between MRP (-) and MRP (+) in those parameter, and no correlation between MRP levels and those parameter. ④ When the RI0 of ~ 99 Tc~m MIBI was chosen as the positive threshold,the sensitive and specificity was 84.62% and 83.33% respectively, and the positive and negative predictive was 84.62% and 83.33%. ⑤ There was significant difference between RI0 group and RI0 group in expression of P-gp, however, no difference in expression of MRP. Conclusion The RI of ~ 99 Tc~m MIBI is the most useful parameter among EUR,DUR and RI for predicting MDR in primary lung cancer. The relationship between ~ 99 Tc~m-MIBI imaging and the expression of MRP should be validated by a larger series of study after following." @default.
- W2350578093 created "2016-06-24" @default.
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- W2350578093 date "2006-01-01" @default.
- W2350578093 modified "2023-09-25" @default.
- W2350578093 title "Correlation between uptake of ~(99)Tc~m-MIBI and expression of multidrug resistant protein in primary lung cancer" @default.
- W2350578093 hasPublicationYear "2006" @default.
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