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- W2350579698 abstract "Objective To investigate the inhibitive effects of trichostation A(TSA) with different concentrations on oral cancer Tca-8113 cells and telomerase activity,and to provide experimental proof for the clinical applications of TSA in anticancer chemotherapy.Methods Tca-8113 cells were treated by TSA with different concentrations,and morphology of cells was examined by transmission electron microscope;proliferative activity of cells was assessed by using MTT so that the concentration of TSA and the time-point could be determined for the follow-up experiment;Telomerase activity was examined by using TRAP-PCR,and hTERT protein was analyzed by Western blotting.Results A time-and dose-dependent inhibition was detected in Tca-8113 treated by TSA.Both the telomerase activity and the expression level of hTERT decreased after TSA treatment.Conclusion The results indicated that TSA can effectively inhibit the proliferation of Tca-8113 cells and thus reduce the telomerase activity and expression level of hTERT,which might be one of the mechanisms for the anticancer function of TSA." @default.
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- W2350579698 date "2010-01-01" @default.
- W2350579698 modified "2023-09-24" @default.
- W2350579698 title "The effects of TSA on the inhibition of Tca-8113 cell and on telomerase" @default.
- W2350579698 hasPublicationYear "2010" @default.
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