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- W2350603086 abstract "Objective To set up a mouse model infected by human HBV C genotype DNA,and to investigate its mechanism and potential therapeutic strategy. Methods A 1.2-genome length HBV C genotype inserted in AVV vector,the recombinant expressed vector pZAC2.1-HBV was successfully constructed. Results After transient transfection in HepG2 cells,HBsAg was detected in cell supernate and cell lyses.By hydrodynamic injection of HBV-DNA into the tail veins of C57BL/6 mice,HBsAg and HBeAg were detected in serum of C57BL/6 mice up to 14 days,meanwhile HBV-DNA specific fragment was detected in serum up to 14 days. Conclusion HBV transfected mice model is successfully set up by hydrodynamic injection of HBV-DNA into the mice." @default.
- W2350603086 created "2016-06-24" @default.
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- W2350603086 date "2009-01-01" @default.
- W2350603086 modified "2023-09-24" @default.
- W2350603086 title "A mouse model of acute hepatitis B virus infection constructed by hydrodynamic injection" @default.
- W2350603086 hasPublicationYear "2009" @default.
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