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- W2350605287 abstract "Objective To observe the protective effect of high dose of methylprednisolone(MP) for focal cerebral ischamic/reperfusion damage in rats and explore its mechanism.Methods 48 SD rats were operated to establish focal cerebral I/R model and were divided into A,B groups randomly.10μl MP(90 mg/kg)and NS were injected in to tail fo rats in A and B group respectively.Open field test was used to examine the behavioral changes,TUNEL and Immunohistochemistry were used to observe opopsis of neuronal cells at the central and around the focal cerebral ischemia and to detect the expression of protein HSP27、Cyt-3、Caspase-9.Results The behavioral mark and the number of apoptosis neurons at the central and around the focal cerebral ischemia were much less in MP group than that in I/R group,and the expression of Hsp27 was increased,while Cyt-3、Caspase-9 was decreased(all above P0.01).Conclusions High dose of MP can significantly protect neurons against cerebral ischemia,moding the expression of HSP27/DISC may be one of the protective mechanism." @default.
- W2350605287 created "2016-06-24" @default.
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- W2350605287 date "2009-01-01" @default.
- W2350605287 modified "2023-09-28" @default.
- W2350605287 title "Protective effect and mechanism of high dose of methylprednisolone for focal cerebral ischamic/reperfusion damage in rats" @default.
- W2350605287 hasPublicationYear "2009" @default.
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