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- W2350620050 abstract "Objective To investigate the effect of andrographolide( AG),an effective component of Traditional Chinese medicine,on the adhesion of fluconazole-resistant Candida albicans isolate. Methods XTT assay was used to evaluate the effect of AG against the adhesion of a fluconazole-resistant Candida albicans isolate. Inverted microscope was applied to observe the morphological changes of biofilm treated with AG. The real-time fluorescence quantification PCR was adopted to inspect adhesion-related gene expressions of ALS3,EAP1,and ALS1. Results AG obviously intervened the adhesion of Candida albicans during the early stage( 2 h),and the expressions of ALS3 and EAP1 were inhibited dramatically,while the expression of ALS1 was upregulated,according to qRTPCR. Conclusion AG could inhibit early adhesion of fluconazole-resistant Candida albicans by downregulating the expressions of some adhesion-related genes." @default.
- W2350620050 created "2016-06-24" @default.
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- W2350620050 date "2014-01-01" @default.
- W2350620050 modified "2023-09-23" @default.
- W2350620050 title "Effect of andrographolide on adhesion of fluconazole-resistant Candida albicans" @default.
- W2350620050 hasPublicationYear "2014" @default.
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