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- W2350620324 abstract "Objective To study the relationship of microvessel density(MVD) the expression of p53 and proliferating cell nuclear antigen(PCNA) to HCC.Methods Anti-CD_ 34,Anti-p53 and Anti-PCNA monoclonal antibodies were used for immunohistochemical staining on surgical specimens from 47 HCC.MVD was counted and the 5-years survival rate was analyzed retrospectively.Results Blood vessels endothelial cells inside the tumor were strongly stained by anti-CD_ 34 antibody,but not stained in the adjacent liver tissues.The MVD levels of the HCC in patients (41.19±15.31)survivaed for more than 5-years were significantly lower than that(54.73±24.72) in survivors for less than 5-years(P0.05).Statistical analysis showed that the MVD levels were not correlated with tumor size,Edmondson′s grade,and alpha-fetoprotein level,neither correlated with the expression of PCNA level or p53 protein(P0.05).However the 5-years survival rate of the p53 positive cases was lower than that of the p53 negative cases(P0.01),and the difference of PCNA was significant between high and low Edmondson′s grade(P0.01).Conclusion In HCC,MVD and abnormal p53 expression separately make worse on 5-years survival rate.However,there are no significant correlation among MVD,p53 and PCNA levels each other." @default.
- W2350620324 created "2016-06-24" @default.
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- W2350620324 date "2001-01-01" @default.
- W2350620324 modified "2023-09-23" @default.
- W2350620324 title "The Relationship of Microvessel Density,p53 and Proliferating Cell Nuclear Antigen to Hepatocellular Carcinoma" @default.
- W2350620324 hasPublicationYear "2001" @default.
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