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- W2350621316 abstract "Objective To evaluate the clinical value of monocyte chemoattractant protein-1 (MCP-1) and N-acety1-beta-D-glucosaminidase (NAG) in diabetic nephropathy (DN).Methods Sixty cases with diabetes mellitus were divided into three groups:normal albuminuria,microalbuminuria and macroalbuminuria.The levels of MCP-1,NAG,Scr and GHbAlc were measured.The relationships between MCP-1and UAER,GHbA1c and NAG were analyzed.Results The levels of urinary MCP-1,NAG in all patients were obviously higher than those in healthy controls(P0.05),the levels of urinary MCP-1,NAG in macroalbuminuria group were the highest.Moreover,the urinary MCP-1 in patients with diabetic nephropathy increased gradually in accordance with the clinical stage of the disease.But the level of serum MCP-1 in all patients was not obviously different from the healthy controls.The levels of urinary MCP-1 were positively correlated with NAG,GHbA1c,and UAER in diabetes mellitus (DM).Conclusion The high level of urinary MCP-1 is associated with the development and progression of DN.Increased urinary expression of MCP-1 in the renal tubuli accelerates tubulointerstitial damage." @default.
- W2350621316 created "2016-06-24" @default.
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- W2350621316 date "2006-01-01" @default.
- W2350621316 modified "2023-09-28" @default.
- W2350621316 title "Clinical significance of MCP-1,NAG in patients with diabetic nephropathy" @default.
- W2350621316 hasPublicationYear "2006" @default.
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