Matches in SemOpenAlex for { <https://semopenalex.org/work/W2350626052> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2350626052 abstract "Background and objective Epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) show promising therapeutic effects in patients with advanced non-small cell lung cancer(NSCLC). However, despite an initial response to TKIs treatment among responsive patients, most inevitably acquire resistance after a progression-free period of about 10 months. The percentage of T790 M in TKI acquired-resistant patients in most studies is around 50%. The aim of this study is to assess the effects of the sequential administration of triptolide and geftinib on cell proliferation and apoptosis of lung adenocarcinoma cell H1975. Methods A MTT assay was used to measure cell proliferation. The potency of the sequential administration of triptolide and geftinib were determined by isobolograms and combination index(CI). Cell apoptosis and cycle distribution were detected by flow cytometry. The Hoechst 33258 method was used to observe the apoptotic morphology. Chemical colorimetric luminescence was used to measure the caspase activity. Results The results of isobolograms and CI showed that the sequential administration of triptolide following geftinib remarkably inhibited cell proliferation and cell apoptosis compared with other sequential administration models. The cycle distribution results indicated that sequential triptolide administration following geftinib blocked the cells in the G2/M phase but not in the G0/G1 phase. The activation of the Caspase-9/Caspase-3 cascade was mainly involved in the apoptotic pathway of lung adenocarcinoma cell H1975 in all sequential administration models. Conclusion The triptolide administration following geftinib might be a new therapeutic strategy for lung cancer with T790 M mutation after having EGFR-TKIs resistance." @default.
- W2350626052 created "2016-06-24" @default.
- W2350626052 creator A5011366353 @default.
- W2350626052 date "2015-01-01" @default.
- W2350626052 modified "2023-09-27" @default.
- W2350626052 title "Sequence-dependent Effect of Triptolide with Gefitinib on the Proliferation and Apoptosis of Lung Adenocarcinoma Cell H1975" @default.
- W2350626052 hasPublicationYear "2015" @default.
- W2350626052 type Work @default.
- W2350626052 sameAs 2350626052 @default.
- W2350626052 citedByCount "0" @default.
- W2350626052 crossrefType "journal-article" @default.
- W2350626052 hasAuthorship W2350626052A5011366353 @default.
- W2350626052 hasConcept C121608353 @default.
- W2350626052 hasConcept C126322002 @default.
- W2350626052 hasConcept C1491633281 @default.
- W2350626052 hasConcept C190283241 @default.
- W2350626052 hasConcept C203014093 @default.
- W2350626052 hasConcept C2776256026 @default.
- W2350626052 hasConcept C2779438470 @default.
- W2350626052 hasConcept C2780580887 @default.
- W2350626052 hasConcept C2780783641 @default.
- W2350626052 hasConcept C2781164371 @default.
- W2350626052 hasConcept C2781182431 @default.
- W2350626052 hasConcept C29537977 @default.
- W2350626052 hasConcept C502942594 @default.
- W2350626052 hasConcept C553184892 @default.
- W2350626052 hasConcept C55493867 @default.
- W2350626052 hasConcept C62112901 @default.
- W2350626052 hasConcept C71924100 @default.
- W2350626052 hasConcept C86803240 @default.
- W2350626052 hasConcept C98274493 @default.
- W2350626052 hasConceptScore W2350626052C121608353 @default.
- W2350626052 hasConceptScore W2350626052C126322002 @default.
- W2350626052 hasConceptScore W2350626052C1491633281 @default.
- W2350626052 hasConceptScore W2350626052C190283241 @default.
- W2350626052 hasConceptScore W2350626052C203014093 @default.
- W2350626052 hasConceptScore W2350626052C2776256026 @default.
- W2350626052 hasConceptScore W2350626052C2779438470 @default.
- W2350626052 hasConceptScore W2350626052C2780580887 @default.
- W2350626052 hasConceptScore W2350626052C2780783641 @default.
- W2350626052 hasConceptScore W2350626052C2781164371 @default.
- W2350626052 hasConceptScore W2350626052C2781182431 @default.
- W2350626052 hasConceptScore W2350626052C29537977 @default.
- W2350626052 hasConceptScore W2350626052C502942594 @default.
- W2350626052 hasConceptScore W2350626052C553184892 @default.
- W2350626052 hasConceptScore W2350626052C55493867 @default.
- W2350626052 hasConceptScore W2350626052C62112901 @default.
- W2350626052 hasConceptScore W2350626052C71924100 @default.
- W2350626052 hasConceptScore W2350626052C86803240 @default.
- W2350626052 hasConceptScore W2350626052C98274493 @default.
- W2350626052 hasLocation W23506260521 @default.
- W2350626052 hasOpenAccess W2350626052 @default.
- W2350626052 hasPrimaryLocation W23506260521 @default.
- W2350626052 hasRelatedWork W1577062926 @default.
- W2350626052 hasRelatedWork W1593544014 @default.
- W2350626052 hasRelatedWork W1951741034 @default.
- W2350626052 hasRelatedWork W2005233860 @default.
- W2350626052 hasRelatedWork W2015539914 @default.
- W2350626052 hasRelatedWork W2039481576 @default.
- W2350626052 hasRelatedWork W2096793135 @default.
- W2350626052 hasRelatedWork W2114865501 @default.
- W2350626052 hasRelatedWork W2150373927 @default.
- W2350626052 hasRelatedWork W2157514563 @default.
- W2350626052 hasRelatedWork W2368354154 @default.
- W2350626052 hasRelatedWork W2371478893 @default.
- W2350626052 hasRelatedWork W2559746534 @default.
- W2350626052 hasRelatedWork W2566838702 @default.
- W2350626052 hasRelatedWork W2803655706 @default.
- W2350626052 hasRelatedWork W2902084106 @default.
- W2350626052 hasRelatedWork W2981036811 @default.
- W2350626052 hasRelatedWork W2982653599 @default.
- W2350626052 hasRelatedWork W2992032646 @default.
- W2350626052 hasRelatedWork W3007348483 @default.
- W2350626052 isParatext "false" @default.
- W2350626052 isRetracted "false" @default.
- W2350626052 magId "2350626052" @default.
- W2350626052 workType "article" @default.