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- W2350632806 abstract "The labeling method for 177Lu-DTPA-BIS-BIOTIN was established,and the biodistribution of 177Lu-DTPA-BIS-BIOTIN in normal mice was carried out as well.Under the optimal experimental condition(DTPA-BIS-BIOTIN 25 μg,pH=4.5 reacting at 80 ℃ for 20 min),the labeling yield of 177Lu-DTPA-BIS-BIOTIN is more than 99.0%.177Lu-DTPA-BIS-BIOTIN shows pretty good in vitro stability.The biodistribution of 177Lu-DTPA-BIS-BIOTIN in normal mice shows a rapid blood clearance.The uptake of 177Lu-DTPA-BIS-BIOTIN is mainly accumulated in liver,spleen and kidney.177Lu-DTPA-BIS-BIOTIN is excreted by kidney.The results provide the basis for further study on 177Lu-DTPA-BIS-BIOTIN used in pretargeted radioimage and radiotherapy of cancer." @default.
- W2350632806 created "2016-06-24" @default.
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- W2350632806 date "2010-01-01" @default.
- W2350632806 modified "2023-09-28" @default.
- W2350632806 title "Preparation of ~(177)Lu-DTPA-BIS-BIOTIN and Biodistribution Evaluation in Normal Mice" @default.
- W2350632806 hasPublicationYear "2010" @default.
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