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- W2350639364 abstract "Objective This study was designed to investigate the expression and significance of COX-2 and the relationship between COX-2 and VEGF in hepatocellular carcinoma. Methods The expression of COX-2 and VEGF were determined by immunohistochemical method in the samples of hepatocellular carcinoma.Results The rate of positive expression COX-2 was 73.3%, 81.3% and 100% in HCC tissues with adjacent nontumorous livers and normal hepatic tissue. The well differentiated HCC expressed that the COX-2 protein was stronger than the moderate and poor differentiate HCC(P 0.05). There was no significant relationship between the intensity of COX-2 expression and age, sex, tumor size, tumorcapsule, presence of portal vein thrombosis and the level of fetoprotein (P 0.05). COX-2 expression was significantly correlated with VEGF expression (P 0.01) and tumor MVD(P 0.05) in hepatocellular carcinoma.Conclusion COX-2 may stimulate angiogenesis through VEGF upregulation." @default.
- W2350639364 created "2016-06-24" @default.
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- W2350639364 date "2005-01-01" @default.
- W2350639364 modified "2023-09-25" @default.
- W2350639364 title "Cyclooxygenase-2 Expression in Human Hepatocellular Carcinoma and Its Relationship with Angiogenesis" @default.
- W2350639364 hasPublicationYear "2005" @default.
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