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- W2350651063 abstract "To study the optimum ultrasonic-assisted chiral resolution condition of bupivacaine racemate,response surface methodology( RSM) based on Box-Benhnken experimental design model was applied to optimize the conditions of chiral resolution. The effects of independent variables,including ultrasound power,solvent amount and resolution temperature were investigated,and the resolution effect was evaluated by purity and yield of levobupivacaine. The optimal resolution condition for levobupivacaine within the experimental range of the variables researched was as follows: ultrasound power of 300 W,solvent amount of 4. 8 mL / g racemate and resolution temperature of 60 ℃. Under this condition,the yield and purity of levobupivacaine were predicted to be 90. 4% and 96. 4% respectively, and corresponding experiment results were 89. 5% and 96. 2%,which demonstrated that it was feasible to optimize the resolution of bupivacaine by using RSM. Compared with the reported results, ultrasonic-assisted has obvious strengthening effects on chiral resolution of bupivacaine racemate." @default.
- W2350651063 created "2016-06-24" @default.
- W2350651063 creator A5024209076 @default.
- W2350651063 date "2013-01-01" @default.
- W2350651063 modified "2023-09-26" @default.
- W2350651063 title "Optimization of ultrasonic-assisted chiral resolution of bupivacaine with response surface method" @default.
- W2350651063 hasPublicationYear "2013" @default.
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