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- W2350663602 abstract "Objective To investigate the potential anti-atherosclerosis(AS)mechanism of lovastatin by observing the influence of lovastatin on the expressions of monocyte chemotactic protein-1(MCP-1)and interleukin 10(IL-10) in human umbilical vein endothelial cells(HUVECs)treated with tumor necrosis factor-α(TNF-α).Methods The HUVECs were routinely cultured in the medium RPMI 1640containing 10%fetal bovine serum(FBS)in vitro and divided into 3groups:control group,TNF-αtreated group(RPMI 1640medium +TNF-α(20μg·L-1),and lovastatin treated group(RPMI 1640medium +20μg·L-1 TNF-α+10μmol·L-1 Lovastatin);Application kit to detect ROS content;Real-time RT-PCR was used to measure the mRNA expressions of MCP-1and IL-10in HUVECs in each group;Western blotting method was used to analyze the protein expressions of MCP-1,NFκB and IL-10in HUVECs in each group.Results Compared with the control group,the expressions of ROS in TNF-α treated group were enhanced obviously(P0.05).Compared with TNF-αtreated group,the ROS expressions in the lovastatin treated group were decreased significantly(P0.05).Compared with control group,the mRNA and protein expression levels of MCP-1and NFκB in TNF-αtreated group were enhanced obviously(P0.05),and the mRNA and protein expression levels of IL-10 were decreased statistically(P0.05).Compared with TNF-α treated group,the mRNA and protein expression levels of MCP-1and NFκB in lovastatin treated group were decreased significantly(P0.05),but the expression level of IL-10 was increased statistically(P 0.05).Conclusion Lovastatin can inhibit the up-regulation of MCP-1and NFκB and increase the expression of IL-10in the HUVECs treated with TNF-α.Lavastatin may inhibit inflammation and prevent artherosclerosis through NF-κB pathway." @default.
- W2350663602 created "2016-06-24" @default.
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- W2350663602 date "2013-01-01" @default.
- W2350663602 modified "2023-09-26" @default.
- W2350663602 title "Influence of lovastatin in expressions of MCP-1 and IL-10 of HUVECs treated with TNF-α" @default.
- W2350663602 hasPublicationYear "2013" @default.
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