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- W2350678370 abstract "Objective To establish an animal model of acidosis-induced retinopathy(AIR),analyze the expression of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF) in a rat model of acidosis-induced retinopathy and to elucidate the action of VEGF and PEDF in the process of neovascularization in retinopathy of prematurity(ROP).Methods Newborn Sprague-Dawley rats were randomly divided into acidosis-induced retinopathy group(ROP group) and control group.Reversal transcription-polymerase chain reaction(RT-PCR) was used to quantify the changes of VEGF mRNA and PEDF mRNA in each group.Results RT-PCR showed that the transcription of VEGF mRNA of ROP group at the 8th was significantly lower than control group,and started to gradually increas after stopping the NH4Cl feeding.Especially on the 10th and 13th day,the transcription of VEGF mRNA of ROP group is much higher than the control group.The changes of PEDF mRNA were opposite to VEGF mRNA.The retina VEGF/PEDF mRNA retio of ROP group decreased significantly than the control group during asidosis,and increased when tubal feeding of NH4Cl was stopped.Conclusions The periods of acidosis result in down-regulation of VEGF and up-regulation of PEDF.The time course of the VEGF/PEDF ratio change correlats with the progression of retinal neovascularization.These results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization.The abnormal retina VEGF/PEDF retio may play an important role in the development of neovascularization in ROP." @default.
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- W2350678370 date "2009-01-01" @default.
- W2350678370 modified "2023-09-26" @default.
- W2350678370 title "Expression of VEGF and PEDF in a rat model of acidosis-induced retinopathy" @default.
- W2350678370 hasPublicationYear "2009" @default.
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