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• W2350692531 abstract "Objective To evaluate the value of color Doppler ultrasonography detected hepatic vein,portal vein and hepatic artery hemodynamic features in the diagnosis of liver fibrosis among infants with biliary atresia(BA).Methods Twenty-two infants diagnosed as BA,were recruited in the study.The infants of BA group were classified into three hepatic fibrosis grades according to the pathology.There were nine infants with low-grade liver fibrosis(S1-S2),seven with moderate-grade(S3),six with high-grade(S4).Twenty-three infants(age and gender matching)without known hepatic,cardiac,or pulmonary disease were set as control.The diameters of hepatic vein,portal vein and hepatic artery were measured,the flow patterns were observed by color Doppler ultrasonography,the hemodynamic parameters were measured.The parameters of the hepatic vein included hepatic vein diameter(HVD),the maximum velocity(HVVmax)and the minimum velocity(HVVmin).The portal vein parameters included portal vein diameter(PVD)and the maximum velocity(PVVmax).The hepatic artery parameters included hepatic artery diameter(HAD),the maximum velocity(HAVmax),the time average velocity(HAVtam)and the resistance index(HARI).Hepatic vein damping index(HVDI),the rate of the maximum velocity of hepatic artery and portal vein(A/P)were also calculated.Results In the BA group,31.8%(7/22)of the infants presented as HV0 hepatic venous flow pattern,63.6%(14/22)as HV1 pattern,4.5%(1/22)as HV2 pattern.In the control group,39.1%(9/23)showed as HV0 pattern,47.8%(11/23)as HV1 pattern,13.0%(3/23)as HV2 pattern.The difference of hepatic venous flow pattern between the BA group and the control was not significant(χ2=1.589,P=0.452).The HVD was(2.37±0.56)mm in BA group,(2.58±0.53)mm in control group,with no significant difference(t=1.681,P=0.108).In the BA group,The HVDI(0.79±0.07)was significantly higher than that of the control(0.55±0.20)(t=2.747,P=0.023).The HVD in the low-,moderate-and high-grade fibrosis cases were(2.52±0.61),(2.24±0.69)and(2.30±0.30)mm.The HVDI were(0.75±0.09),(0.78±0.13),(0.79±0.05)respectively.The difference of HVD in each fibrosis case was not significant(P0.05).While the HVDI in each fibrosis case was different significantly,the HVDI in the high-grade fibrosis cases was significantly higher than that of the low-grade fibrosis cases(χ2=-2.401,P=0.016).The PVD and PVVmax between the BA group[(3.93±0.76)mm,(23.6±8.0)cm/s]and the control group[(3.79±0.66)mm,(23.1±5.5)cm/s]were not significantly different(t=0.659,0.685,both P0.05).The PVD in the low-,moderate-and high-grade fibrosis cases was(3.91±0.82),(4.00±0.62)and(3.88±0.95) mm,respectively,the PVVmax were(22.6±7.1),(24.2±8.0) and(24.4±10.0)cm/s,respectively,which had no significant difference.the HAD in BA group [(2.01±0.32)mm] was significantly larger(t=8.908,P=0.000)than that in control group[(1.24±0.38)mm].HAVmax in the BA group [108.3±49.7]cm/s] was significant higher(t=5.181,P=0.000)than that in the control group[(47.5±18.4)cm/s].The HAVtam was(51.6±24.6)cm/s in the BA group,and(22.9±8.3)cm/s in the control,the difference was significant(t=5.018,P=0.000).The RI between the BA(0.81±0.06)and control group(0.77±0.06)was not significantly different(t=1.910,P=0.070).The A/P of BA group(6.76±5.17)was significantly higher(t=3.434,P=0.002)than that of the control(2.26±0.95).The differences of the HAD,HAVmax,HAVtam in the fibrosis groups were not significant(χ2=0.999,0.602,1.175,1.233,all P0.05),while the HARI was significantly different(χ2=7.891,P=0.019).The HARI in the high-grade fibrosis group(0.86±0.04) was significantly higher(χ2=-2.911,P=0.004)than low-grade fibrosis groups(0.78±0.06).The HA spectrum of the BA group was higher and sharper that that in the control.Conclusions In infants with biliary atresia,the enlarged diameter and enhanced maximum velocity of hepatic artery is valuable for the diagnosis of liver fibrosis,the HARI is helpful for predicting the degree of liver fibrosis.The HVDI is valuable for the diagnosis of liver fibrosis in the infants with biliary atresia,while the color Doppler characteristics of the portal vein were not as valuable for the diagnosis." @default.
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• W2350692531 title "Value of color Doppler ultrasonography in evaluating the vascular hemodynamic change of liver fibrosis in infants with biliary atresia" @default.
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