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- W2350709708 abstract "Objective:To evaluate the effect of aspirin and cilostazol on aggregation of platelet in coronary heart disease(CHD) patients with or without diabetes.Methods:The 45 CHD patients with type 2 diabetes mellitus(DM) and 45 CHD patients without DM were selected according to inclusive criteria.Two groups were divided into aspirin groups,cilostaxol groups and combinative groups according to administer drugs respectively.The aggregation of activated platelet,TXB2,6-K-PGF1a and MPO were detected and analyzed for their correlation.Those data were compared among groups.Results:(1)Multivariate correlative analysis showed that blood glucose was the most important factor correlated with the aggregation of activated platelet(R=0.914,P0.01);(2)Compared the without diabetes group,the level of aggregation of activated platelet,TXB2,MPO increased,the level of 6-K-PGF1a decreased in CHD patients with diabetes group;(3)For patients without DM,the level of aggregation of activated platelet and TXB2 had no significant difference between aspirin and cilostazol groups,the level of 6-K-PGF1a was higher,while the level of MPO was lower in cilostazol group than those of aspirin group(P0.001).For patients with DM,the level of the aggregation of activated platelet,TXB2,MPO were lower while the level of 6-K-PGF1a was higher in cilostazol group than those of aspirin group(P0.05~0.001).Conclusion:Cilostazol is more effective than aspirin to inhibit the aggregation of activated platelet for CHD patients with DM." @default.
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- W2350709708 date "2007-01-01" @default.
- W2350709708 modified "2023-09-26" @default.
- W2350709708 title "Effect of aspirin and cilostazol on aggregation of platelet in coronary artery disease patients with or without diabetes" @default.
- W2350709708 hasPublicationYear "2007" @default.
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